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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1923 1
1955 1
1966 1
1967 1
1968 1
1969 1
1970 1
1971 4
1972 6
1973 5
1974 7
1975 21
1976 16
1977 8
1978 17
1979 27
1980 21
1981 18
1982 13
1983 30
1984 38
1985 28
1986 30
1987 42
1988 35
1989 41
1990 41
1991 50
1992 48
1993 68
1994 88
1995 87
1996 111
1997 104
1998 137
1999 157
2000 181
2001 172
2002 174
2003 193
2004 253
2005 294
2006 300
2007 314
2008 366
2009 395
2010 368
2011 372
2012 408
2013 399
2014 427
2015 411
2016 437
2017 422
2018 383
2019 409
2020 420
2021 413
2022 322
2023 292
2024 98

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8,635 results

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Page 1
Disrupting the phase separation of KAT8-IRF1 diminishes PD-L1 expression and promotes antitumor immunity.
Wu Y, Zhou L, Zou Y, Zhang Y, Zhang M, Xu L, Zheng L, He W, Yu K, Li T, Zhang X, Chen Z, Zhang R, Zhou P, Zhang N, Zheng L, Kang T. Wu Y, et al. Nat Cancer. 2023 Mar;4(3):382-400. doi: 10.1038/s43018-023-00522-1. Epub 2023 Mar 9. Nat Cancer. 2023. PMID: 36894639 Free PMC article.
Here, we report that in cells exposed to interferon-gamma (IFNgamma), KAT8 undergoes phase separation with induced IRF1 and forms biomolecular condensates to upregulate PD-L1. Multivalency from both the specific and promiscuous interactions between IRF1 and KAT8 is require …
Here, we report that in cells exposed to interferon-gamma (IFNgamma), KAT8 undergoes phase separation with induced IRF1 and forms biomolecul …
RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation.
Guillén-Boixet J, Kopach A, Holehouse AS, Wittmann S, Jahnel M, Schlüßler R, Kim K, Trussina IREA, Wang J, Mateju D, Poser I, Maharana S, Ruer-Gruß M, Richter D, Zhang X, Chang YT, Guck J, Honigmann A, Mahamid J, Hyman AA, Pappu RV, Alberti S, Franzmann TM. Guillén-Boixet J, et al. Cell. 2020 Apr 16;181(2):346-361.e17. doi: 10.1016/j.cell.2020.03.049. Cell. 2020. PMID: 32302572 Free PMC article.
Subsequent physical crosslinking of G3BP clusters drives RNA molecules into networked RNA/protein condensates. We show that G3BP condensates impede RNA entanglement and recruit additional client proteins that promote SG maturation or induce a liquid-to-solid transit …
Subsequent physical crosslinking of G3BP clusters drives RNA molecules into networked RNA/protein condensates. We show that G3BP c …
Condensation of LINE-1 is critical for retrotransposition.
Sil S, Keegan S, Ettefa F, Denes LT, Boeke JD, Holt LJ. Sil S, et al. Elife. 2023 Apr 28;12:e82991. doi: 10.7554/eLife.82991. Elife. 2023. PMID: 37114770 Free PMC article.
LINE-1 (L1) is the only autonomously active retrotransposon in the human genome, and accounts for 17% of the human genome. ...Mutations that prevented ORF1p condensation led to loss of retrotransposition activity, while orthogonal restoration of coiled-coil conforma …
LINE-1 (L1) is the only autonomously active retrotransposon in the human genome, and accounts for 17% of the human genome. ...Mutatio …
Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization.
Sanders DW, Kedersha N, Lee DSW, Strom AR, Drake V, Riback JA, Bracha D, Eeftens JM, Iwanicki A, Wang A, Wei MT, Whitney G, Lyons SM, Anderson P, Jacobs WM, Ivanov P, Brangwynne CP. Sanders DW, et al. Cell. 2020 Apr 16;181(2):306-324.e28. doi: 10.1016/j.cell.2020.03.050. Cell. 2020. PMID: 32302570 Free PMC article.
Liquid-liquid phase separation (LLPS) mediates formation of membraneless condensates such as those associated with RNA processing, but the rules that dictate their assembly, substructure, and coexistence with other liquid-like compartments remain elusive. ...Inspired by pa …
Liquid-liquid phase separation (LLPS) mediates formation of membraneless condensates such as those associated with RNA processing, bu …
The dual nature of the nucleolus.
Tartakoff A, DiMario P, Hurt E, McStay B, Panse VG, Tollervey D. Tartakoff A, et al. Genes Dev. 2022 Jul 1;36(13-14):765-769. doi: 10.1101/gad.349748.122. Genes Dev. 2022. PMID: 36342833 Free PMC article. Review.
The nucleolus is best known for housing the highly ordered assembly line that produces ribosomal subunits. The >100 ribosome assembly factors in the nucleolus are thought to cycle between two states: an operative state (when integrated into subunit assembly intermediate …
The nucleolus is best known for housing the highly ordered assembly line that produces ribosomal subunits. The >100 ribosome assem …
A condensate-hardening drug blocks RSV replication in vivo.
Risso-Ballester J, Galloux M, Cao J, Le Goffic R, Hontonnou F, Jobart-Malfait A, Desquesnes A, Sake SM, Haid S, Du M, Zhang X, Zhang H, Wang Z, Rincheval V, Zhang Y, Pietschmann T, Eléouët JF, Rameix-Welti MA, Altmeyer R. Risso-Ballester J, et al. Nature. 2021 Jul;595(7868):596-599. doi: 10.1038/s41586-021-03703-z. Epub 2021 Jul 7. Nature. 2021. PMID: 34234347
Biomolecular condensates have emerged as an important subcellular organizing principle(1). ...IBs of negative-strand RNA viruses were recently shown to be biomolecular condensates that form through phase separation(4,5). Here we report that the steroidal alkaloid cy …
Biomolecular condensates have emerged as an important subcellular organizing principle(1). ...IBs of negative-strand RNA viruses were …
Remodeling of Biomembranes and Vesicles by Adhesion of Condensate Droplets.
Lipowsky R. Lipowsky R. Membranes (Basel). 2023 Feb 10;13(2):223. doi: 10.3390/membranes13020223. Membranes (Basel). 2023. PMID: 36837726 Free PMC article. Review.
Condensate droplets are formed in aqueous solutions of macromolecules that undergo phase separation into two liquid phases. ...In this review, I address the interactions of condensate droplets with biomimetic and biological membranes. When a condensate drople …
Condensate droplets are formed in aqueous solutions of macromolecules that undergo phase separation into two liquid phases. ...In thi …
Pol II phosphorylation regulates a switch between transcriptional and splicing condensates.
Guo YE, Manteiga JC, Henninger JE, Sabari BR, Dall'Agnese A, Hannett NM, Spille JH, Afeyan LK, Zamudio AV, Shrinivas K, Abraham BJ, Boija A, Decker TM, Rimel JK, Fant CB, Lee TI, Cisse II, Sharp PA, Taatjes DJ, Young RA. Guo YE, et al. Nature. 2019 Aug;572(7770):543-548. doi: 10.1038/s41586-019-1464-0. Epub 2019 Aug 7. Nature. 2019. PMID: 31391587 Free PMC article.
Both the transcription-initiation machinery and the splicing machinery can form phase-separated condensates that contain large numbers of component molecules: hundreds of molecules of Pol II and mediator are concentrated in condensates at super-enhancers(7,8), and l …
Both the transcription-initiation machinery and the splicing machinery can form phase-separated condensates that contain large number …
Germ Granules in Animal Oogenesis.
Dobrynin MA, Bashendjieva EO, Enukashvily NI. Dobrynin MA, et al. J Dev Biol. 2022 Oct 9;10(4):43. doi: 10.3390/jdb10040043. J Dev Biol. 2022. PMID: 36278548 Free PMC article. Review.
In eukaryotic cells, many macromolecules are organized as membraneless biomolecular condensates (or biocondensates). Liquid-liquid and liquid-solid phase transitions are the drivers of the condensation process. The absence of membrane borders makes biocondensates ve …
In eukaryotic cells, many macromolecules are organized as membraneless biomolecular condensates (or biocondensates). Liquid-liquid an …
Dropwise Condensate Comb for Enhanced Heat Transfer.
Tang Y, Yang X, Wang L, Li Y, Zhu D. Tang Y, et al. ACS Appl Mater Interfaces. 2023 May 3;15(17):21549-21561. doi: 10.1021/acsami.2c20874. Epub 2023 Apr 21. ACS Appl Mater Interfaces. 2023. PMID: 37083343
Here, we introduced a dropwise condensate comb, which consisted of U-shaped protruding hydrophilic stripes and hierarchical micro-nanostructured superhydrophobic background, for a better control of condensation droplet size and departure processes. The dropwise c …
Here, we introduced a dropwise condensate comb, which consisted of U-shaped protruding hydrophilic stripes and hierarchical micro-nan …
8,635 results